Does spatial distribution of Mg2+ transporters support Mg2+ absorptive function of human skin?

Werner T1,Trancikova A2, Adamkov M3, Dobrota D4, Racay P2, Kolisek M2

1 Protina Pharmazeutische GmbH., Ismaning, Germany
2 BioMed Martin, Jessenius Medical faculty, Commenius University, Martin, Slovakia
3 Institute of Histology and Embryology, Jessenius Medical faculty, Comenius University, Martin, Slovakia
4 Institute of Clinical Biochemistry, Jessenius Medical faculty, Comenius University, Martin, Slovakia

Transdermal ion transport thus the transdermal uptake of charged inorganic species remains heavily debated
and poorly understood. Assumption that transdermal uptake occurs and is a normal physiological function of
human skin serves the base to market various dermal magnesium preparations. There is an increasing rate of
articles in the specialist or lay press as well as in the internet that transdermal magnesium uptake being an
alternative to per oral magnesium supplementation. But is it really true that human skin is capable of
conducting uptake of magnesium that may result in increase of plasma and/or intracellular (blood cellular
species) magnesium concentration?
In this presentation we will critically review the available pool of information and provide pilot experimental
evidence that human skin is not able to support Mg uptake sufficient to complement or replace per oral Mg